Uppsala University scientists have developed a method which identifies what genes are controlled by the gene USF1, upstream transcription factor 1. This gene is known to cause the disease familial combined hyperlipidemia, which can cause disturbed fat metabolism and early heart attacks. A research team led by Claes Wadelius, of the Department of Genetics and Pathology at Uppsala University, in collaboration with Jan Komorrowski at the Linnaeus Center for Bioinformatics, developed a method whereby genes’ transcription factors can be analyzed in living cells, rather than testing synthetic genes in test tubes, and whereby the entire human genome can be analyzed at once, rather than analyzing single genetic fragments. The method showed that USF1 governs more than 1000 genes. Many of these genes determine the body’s levels of fat, and some of them are involved in cell’s enery production.
IDG.se
tisdag 9 februari 2010
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