Ett spårämnes vikt kan vara minst lika användbar som dess strålning. Det visar Martin Lavén vid Uppsala Universitets Kemiska Institution. I sin avhandling har han utvecklat nya metoder som kan leda till ökad kunskap om sjukdomar som depression och schizofreni.
Studera exakt
Med hjälp av positronemissionstomografi, PET, och radioaktiva spårsubstanser kan många frågor besvaras kring sjukdomar och dess skeenden. Det är till exempel möjligt att studera hur läkemedel når hjärnreceptorer och exakt var en cancercell sitter. Men spårsubstanser bryts ner av enzymer och det är viktigt att bestämma hur stor del av spårsubstansen som är intakt vid en PET-undersökning. Det görs oftast genom mätning av strålningen från blod, men metoden är komplicerad eftersom mängden strålning är starkt reducerad i slutet av en undersökning.
Molekylvikt
Martin Lavén har i sitt avhandlingsarbete utvecklat nya masspektrometriska metoder med hög känslighet för att mäta stabiliteten hos olika spårsubstanser. Metoden bygger på att mäta spårmolekylernas vikt och inte deras strålning. På så sätt kan spårsubstansernas stabilitet bestämmas med i princip samma noggrannhet i början av en PET-undersökning som i slutet, och ge PET-data av förbättrad kvalitet. Martin Lavén har utifrån sin egen metod också identifierat en ny stabil spårsubstans som förhoppningsvis ska kunna användas för att bättre förstå och utveckla behandlingar mot sjukdomar som depression och schizofreni.
Studera exakt
Med hjälp av positronemissionstomografi, PET, och radioaktiva spårsubstanser kan många frågor besvaras kring sjukdomar och dess skeenden. Det är till exempel möjligt att studera hur läkemedel når hjärnreceptorer och exakt var en cancercell sitter. Men spårsubstanser bryts ner av enzymer och det är viktigt att bestämma hur stor del av spårsubstansen som är intakt vid en PET-undersökning. Det görs oftast genom mätning av strålningen från blod, men metoden är komplicerad eftersom mängden strålning är starkt reducerad i slutet av en undersökning.
Molekylvikt
Martin Lavén har i sitt avhandlingsarbete utvecklat nya masspektrometriska metoder med hög känslighet för att mäta stabiliteten hos olika spårsubstanser. Metoden bygger på att mäta spårmolekylernas vikt och inte deras strålning. På så sätt kan spårsubstansernas stabilitet bestämmas med i princip samma noggrannhet i början av en PET-undersökning som i slutet, och ge PET-data av förbättrad kvalitet. Martin Lavén har utifrån sin egen metod också identifierat en ny stabil spårsubstans som förhoppningsvis ska kunna användas för att bättre förstå och utveckla behandlingar mot sjukdomar som depression och schizofreni.
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